⚠️ RESEARCH PURPOSES ONLY — This compound is not FDA authorized for human consumption. All referenced data is presented for informational and educational purposes only.
NAD+ 500MG
$75.00
How It Works
Essential coenzyme for cellular energy, DNA repair, and longevity signaling
Mitochondrial Function
NAD+ is essential for mitochondrial electron transport chain function, directly participating in the conversion of nutrients to cellular energy (ATP). Declining NAD+ levels impair mitochondrial efficiency.
- Required for oxidative phosphorylation
- Electron carrier in metabolic reactions
- Supports 500+ enzymatic processes
Sirtuin Activation
NAD+ is the obligate co-substrate for all 7 sirtuin enzymes (SIRT1-7), which regulate aging, inflammation, stress resistance, and metabolic homeostasis. Without NAD+, sirtuins cannot function.
- Activates all 7 sirtuin enzymes
- Regulates aging and stress response
- Modulates inflammatory pathways
PARP & Genomic Stability
PARP enzymes consume NAD+ to repair DNA damage. As NAD+ declines with age, DNA repair capacity decreases, accelerating cellular senescence and genomic instability.
- Fuels PARP-mediated DNA repair
- Maintains genomic stability
- Counters age-related DNA damage
What Research Has Shown
Key findings from NAD+ metabolism research
Research Applications
Primary areas of investigation
Aging & Senescence
NAD+ supplementation extends lifespan in multiple model organisms by activating sirtuin-mediated longevity pathways and improving mitochondrial function.
Covarrubias et al. 2021 ↗Energy Metabolism
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication. Restoring NAD+ reverses age-related metabolic decline in animal models.
Gomes et al. 2013 ↗DNA Repair
NAD+ fuels PARP enzymes responsible for single-strand DNA break repair. Depletion leads to accumulated DNA damage and accelerated cellular aging.
Rajman et al. 2018 ↗UPR Activation
The NAD+/sirtuin pathway modulates longevity through activation of the mitochondrial unfolded protein response (UPRmt), a key stress defense mechanism.
Mouchiroud et al. 2013 ↗Compound Information
Technical specifications