⚠️ RESEARCH PURPOSES ONLY — This compound is not FDA authorized for human consumption. All referenced data is presented for informational and educational purposes only.
Selank 5MG
$30.00
How It Works
Anxiolytic and immunomodulatory mechanisms studied in preclinical and early clinical research
GABA-A Receptor Modulation
Research indicates Selank modulates GABAergic neurotransmission, including GABA-A receptor activity and expression of GABAergic system components. This mechanism is associated with the anxiolytic effects observed in preclinical animal models and early clinical studies, without the sedative or dependency concerns seen with classical benzodiazepines.
- Modulates GABA-A receptor subunit expression
- Anxiolytic effects without benzodiazepine-type sedation
- No reported physical dependence in preclinical models
BDNF & Enkephalin Upregulation
Selank research demonstrates upregulation of brain-derived neurotrophic factor (BDNF) expression and enhancement of enkephalin metabolism. BDNF supports neuroplasticity and synaptic maintenance. Stabilization of enkephalin levels may contribute to the observed mood and cognitive effects in preclinical studies.
- Increases BDNF expression in hippocampal regions
- Stabilizes enkephalin via enkephalinase inhibition
- Modulates serotonin and dopamine turnover
Tuftsin-Derived Immune Regulation
Selank is derived from the immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with a proline-glycine-proline extension that enhances stability. Research demonstrates it modulates cytokine production including IL-6, IL-1β, and TNF-α expression, supporting its investigation as an anxiolytic with immunomodulatory properties.
- Derived from tuftsin (natural immunomodulator)
- Modulates pro-inflammatory cytokine expression
- Influences interferon alpha/gamma signaling pathways
What Research Has Shown
Key preclinical and clinical findings from published studies
Research Applications
Primary areas of investigation
Anxiolytic Mechanisms
Preclinical studies demonstrate anxiolytic effects in elevated plus maze and open field tests, attributed to GABAergic modulation. Selank shows anxiolytic activity comparable to diazepam without sedative side effects in rodent models.
Semenova et al. 2010 ↗Memory & Learning
Research reports improved learning and memory consolidation in animal models of stress-induced cognitive impairment. BDNF upregulation and enkephalin stabilization are proposed as underlying mechanisms supporting synaptic plasticity.
Kozlovskaya et al. 2008 ↗Cytokine & Immune Modulation
Studies report Selank modulates expression of interleukin-6, TNF-α, and interferon signaling pathways, consistent with its tuftsin-derived immunomodulatory origin. Investigated as a model for peptide-based neuroimmunomodulation research.
Zozulya et al. 2012 ↗Transcriptomic Studies
Gene expression studies identify Selank-induced changes in transcription of genes related to serotonin, dopamine metabolism, and synaptic plasticity. Provides a molecular pharmacology research framework for peptide-based anxiolytics.
Inozemtseva et al. 2009 ↗Compound Information
Technical specifications