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⚠️  RESEARCH PURPOSES ONLY — This compound is not FDA authorized for human consumption. All referenced data is presented for informational and educational purposes only.

TB500
Category:

TB-500 5MG

Thymosin Beta-4Tβ4TB4Thymosin β4
A 43-amino acid synthetic fragment of thymosin beta-4 that regulates actin polymerization and promotes cell migration in preclinical research.

$30.00

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🧬
43
Amino Acid Sequence
Fragment of Thymosin Beta-4
📈
61%
Faster Healing
Re-epithelialization vs controls
🔬
170+
Published Studies
Preclinical research papers
✅
99%+
Purity Verified
HPLC tested, COA included

How It Works

Actin-binding peptide that promotes cell migration and tissue repair

Actin Regulation

Cell Migration & Motility

TB-500 binds G-actin monomers and promotes actin polymerization, enabling cells to migrate to injury sites. This is the primary mechanism driving its tissue repair properties in preclinical models.

  • Sequesters G-actin to regulate polymerization
  • Promotes cell migration to injury sites
  • Enhances cytoskeletal remodeling
Cardiac

Cardiac Repair Signaling

In cardiac research, TB-500 activates integrin-linked kinase (ILK) and promotes cardiac progenitor cell migration. Phase II clinical trials have been conducted for cardiac repair applications.

  • Activates integrin-linked kinase (ILK)
  • Promotes cardiac progenitor cell migration
  • Phase II clinical trial data available
Anti-Inflammatory

Inflammation Modulation

TB-500 downregulates pro-inflammatory cytokines and modulates macrophage activity, shifting the immune response from inflammatory to regenerative in preclinical wound models.

  • Reduces pro-inflammatory cytokines
  • Modulates macrophage polarization
  • Supports anti-fibrotic tissue remodeling
📊

What Research Has Shown

Key preclinical and clinical findings

Wound Re-epithelialization 61%
Cell Migration Enhancement 85%
Collagen Deposition 72%
Anti-Inflammatory Effect 68%
🎯

Research Applications

Primary areas of investigation

DERMATOLOGY

Wound Healing

Accelerates dermal wound closure, reduces scarring, and promotes organized collagen deposition in preclinical wound models.

Malinda et al. 2007 ↗
CARDIOVASCULAR

Cardiac Repair

Promotes cardiac cell migration via ILK activation. Phase II clinical trials conducted for post-myocardial infarction repair.

Bock-Marquette et al. 2004 ↗
OPHTHALMOLOGY

Corneal Healing

Promotes corneal epithelial wound healing and reduces inflammation in ocular surface damage models.

Sosne et al. 2018 ↗
MUSCULOSKELETAL

Soft Tissue Repair

Enhances muscle, tendon, and ligament repair through actin-mediated cell migration and reduced fibrotic scarring.

Goldstein et al. 2010 ↗
🧪

Compound Information

Technical specifications

Chemical Name N-Acetyl-L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-\(\alpha \)-glutamyl-L-threonyl-L-glutamine
Sequence Ac-LKKTETQ-OH
Molecular Weight 4,963 Da
Molecular Formula \(C_{38}H_{68}N_{10}O_{14}\)

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